South Asian Journal of Engineering and Technology

Vol. 8 No. 1 (2019): Volume 8, Issue 1, Year 2019
Articles

Membrane stabilization effect and histological changes in the heart in experimental myocardial rats with Zanthoxulym armatum fruit

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  • Malathi Mangalanathan,
  • Tamiloli Devendhiran,
  • Saraswathi Uthamaramasamy,
  • Keerthika Kumarasamy,
  • K Mohanraj,
  • Kannagi Devendhiran,
  • T Suganya,
  • Mei Ching Lin
Malathi Mangalanathan
Department of Biochemistry, PSG College of Arts & Science, Coimbatore- 641014, Tamilnadu, India
Tamiloli Devendhiran
Department and Graduate Institute of Applied Chemistry, Chaoyang University of Technology, No.16, Jifeng East Road, Wufeng District, Taichung City – 41349, Taiwan (R.O.C).
Saraswathi Uthamaramasamy
Department of Biochemistry, PSG College of Arts & Science, Coimbatore- 641014, Tamilnadu, India.
Keerthika Kumarasamy
Department and Graduate Institute of Applied Chemistry, Chaoyang University of Technology, No.16, Jifeng East Road, Wufeng District, Taichung City – 41349, Taiwan (R.O.C).
K Mohanraj
Raman Research Laboratory, PG & Research Department of Physics, Government Arts College, Tiruvannamalai-606603, Tamilnadu, India
Kannagi Devendhiran
Department of Chemistry, Sri Vijay Vidyalaya College of Arts and Science (Women’s college), Dharmapuri, Periyar University, Tamilnadu, India.
T Suganya
Department of Chemistry, Sri Vijay Vidyalaya College of Arts and Science (Women’s college), Dharmapuri, Periyar University, Tamilnadu, India
Mei Ching Lin
Department and Graduate Institute of Applied Chemistry, Chaoyang University of Technology, No.16, Jifeng East Road, Wufeng District, Taichung City – 41349, Taiwan (R.O.C).
DOI: https://doi.org/10.26524/sajet190805

Published 2019-02-08

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Abstract

Membrane bound adenosine triphosphatases (ATPases) shed a massive function into the contraction and relaxation of the heart muscle via keeping the normal ion levels within the myocyte. The current study aims to assess the potency of Zanthoxylum armatum (Z. armatum) fruit on membrane bound ATPases and ions in Isoproterenol (ISO) induced myocardial infracted rats. The hydroethanolic extract of Z. armatum fruit was administered at a dose of 200 and 400mg/kg body weight for 30 days to male Wistar albino rats. On 28th and 29th day, ISO (8.5mg/100g body weight) used to be administered to induce myocardial infarction (MI). ISO treated rats confirmed a significant increase in the levels of tissue sodium (Na+) and calcium (Ca2+) ions and membrane bound Ca2+ ATPase then Mg2+ ATPase activity. A significant decrease in tissue potassium (K+), Na +/K+ ATPase was observed which indicates membrane destabilization. Pretreatment with hydroethanolic extract of Z. armatum fruit to ISO induced rats significantly (p<0.05) prevented the altered membrane bound enzymes to near normal status. The findings of the present study indicate the protective effect of Z. armatum fruit on altered ion pumps and destabilization on the cardiac membrane into ISO induced MI rats which might also be due to the presence of phytoconstituents.

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