South Asian Journal of Engineering and Technology

Vol. 7 No. 3 (2018): Vol 7, Iss 3, Year 2018
Articles

Microwave Synthesis and Characterization of Antibacterial Activity Evaluation of 2-(4, 5-dihydro-5-(4-chlorophenyl)-1H-pyrazol-3-yl) phenol

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  • L Ilavarasan,
  • A Ravi,
  • M Ganapathi,
  • E Subitchayini,
  • K Sivasakthi,
  • R Sapthagiri,
  • J Vinayagam,
  • K Mohanraj,
  • Tamiloli Devendhiran,
  • Keerthika Kumarasamy
L Ilavarasan
PG & Research Department of Chemistry, Government Arts College, Tiruvannamalai. 606 603, Tamilnadu, India.
A Ravi
PG & Research Department of Chemistry, Government Arts College, Tiruvannamalai. 606 603, Tamilnadu, India
M Ganapathi
PG & Research Department of Chemistry, Government Arts College, Tiruvannamalai. 606 603, Tamilnadu, India
E Subitchayini
PG & Research Department of Chemistry, Government Arts College, Tiruvannamalai. 606 603, Tamilnadu, India
K Sivasakthi
PG & Research Department of Chemistry, Government Arts College, Tiruvannamalai. 606 603, Tamilnadu, India
R Sapthagiri
PG & Research Department of Chemistry, Government Arts College, Tiruvannamalai. 606 603, Tamilnadu, India
J Vinayagam
Department of Chemistry, National Tsing Hua University, Taiwan 30013, R.O.C.
K Mohanraj
Raman Research Laboratory, PG & Research Department of Physics, Government Arts College, Tiruvannamalai. 606 603, Tamilnadu, India
Tamiloli Devendhiran
Department and Graduate Institute of Applied Chemistry, Chaoyang University of Technology, Taichung City-41349, Taiwan (R.O.C)
Keerthika Kumarasamy
Department and Graduate Institute of Applied Chemistry, Chaoyang University of Technology, Taichung City-41349, Taiwan (R.O.C).
DOI: https://doi.org/10.26524/sa1

Published 2018-10-18

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Abstract

Chalcone derivatives were synthesized by reaction of some benzaldehyde derivatives with acetophenone, then the products obtained were allowed to react with urea, thiourea and hydroxylamine, to give the heterocyclic derivatives of oxazine, thiazine and isoxazole, respectively.In this study, a series of chalcones and substituted pyrazole compounds were synthesized according to green chemistry methods of conventional and microwave irradiation by using substituted acetophenone, substituted benzaldehyde, hydrazine hydrate and PEG-400. The synthesized compounds were characterized by UV-Visible, FT-IR and 1H NMR spectral techniques. The purity of the synthesized compounds were monitored by TLC and tested for their antibacterial activity by Minimum Inhibitory Concentration (MIC) method against two different microorganisms Staphylococcus auras (MTCC3381), and Escherichia coli (MTCC739).

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